Hypolipidaemic effects of papaya (<i>Carica papaya</i> L.) juice on rats fed on a high fat and fructose diet

Abstract Papaya ( Carica papaya L.) is a highly nutritious and less-caloric fruit, commonly consumed for its minerals vitamins hence may help in controlling obesity abdominal discomforts. The present study investigated the hypolipidaemic effects of juice extract on male Albino Wistar rats (7 weeks old; 185 ± 17 g) fed high fat fructose diet (HFFD) 6 weeks. were divided into groups I–IV five each either HFFD (i.e. Control), + 200 mg papaya, 350 or 500 papaya. On day 34, after an overnight fast, blood samples obtained by cardiac puncture under 99⋅8 % Chloroform anaesthesia determination serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL-c) high-density (HDL-c). atherogenic (AI) coronary risk (CRI) indices also calculated. Statistical analysis was performed using ANOVA where means separated Tukey's HSD test. Resulted showed that all given had increasing, non-significant HDL-c reduced LDL-c levels while highest TC (53⋅2 mg/dl) TG (37⋅6 levels. statistically AI CRI rats. In conclusion, consumption most effective reduction rats’ lipids fats, due to anti-obesity properties, thus can be used management dyspilidaemic disorders.